Tryptophan N-monooxygenase

Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

L-tryptophan 2 O₂ 2 NADPH 2 H ${\displaystyle \rightleftharpoons }$ (E)-indol-3-ylacetaldoxime 2 NADP CO₂ 3 H₂O (overall reaction)

(1a) L-tryptophan O₂ NADPH H ${\displaystyle \rightleftharpoons }$ N-hydroxy-L-tryptophan NADP H₂O

(1b) N-hydroxy-L-tryptophan O₂ NADPH H ${\displaystyle \rightleftharpoons }$ N,N-dihydroxy-L-tryptophan NADP H₂O

(1c) N,N-dihydroxy-L-tryptophan ${\displaystyle \rightleftharpoons }$ (E)-indol-3-ylacetaldoxime CO₂ H₂O

Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).

References

External links

• Tryptophan N-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)